Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5265955 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A method of masking 3â²-H-phosphonate group for the solution-phase synthesis of ribonucleotide by H-phosphonate approach was described. The phosphonic acid group was masked by bis-(2-cyanoethyl) boranophosphate during the reactions. After a successive demasking treatment by triethylamine, trityl cation, and triethylamine, the triethylammonium 3â²-H-phosphonate nucleotide can be obtained efficiently ready for the coupling cycle in synthesis of oligonucleotide.
Related Topics
Physical Sciences and Engineering
Chemistry
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Authors
Jinyu Huang, Wei Lu, Zhen Xi,