Article ID Journal Published Year Pages File Type
5265955 Tetrahedron Letters 2013 4 Pages PDF
Abstract
A method of masking 3′-H-phosphonate group for the solution-phase synthesis of ribonucleotide by H-phosphonate approach was described. The phosphonic acid group was masked by bis-(2-cyanoethyl) boranophosphate during the reactions. After a successive demasking treatment by triethylamine, trityl cation, and triethylamine, the triethylammonium 3′-H-phosphonate nucleotide can be obtained efficiently ready for the coupling cycle in synthesis of oligonucleotide.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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