| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5266001 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
A series of l-prolinamide derivatives have been evaluated as potential organocatalysts for aldol reactions. To synthesize these catalysts, a novel and simple route has been developed using proline N-carboxyanhydride (proline-NCA). A new catalyst with a trifluoromethyl-sulfonamide group has been found exhibiting excellent diastereoselectivity (anti/syn: 97/3) and enantioselectivity (99% ee) with 10 mol % loading and being easily recyclable in water.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gongkun Tang, Xianming Hu, Hans Josef Altenbach,