Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5266032 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
N-heterocyclic carbene (NHC) has been employed as an efficient catalyst for cyanation reaction of carbonyl compounds. Under catalysis of 1 mol % NHCs, various aldehydes and 2,2,2-trifluoroacetophenone coupled with ethyl cyanoformate in THF to provide cyanohydrins ethyl carbonates in excellent yields. While in the presence of 10 mol % catalyst, different types of aldehydes and 2,2,2-trifluoroacetophenone reacted with acetyl cyanide in dichloroethane to give acylated cyanohydrins in moderate to high yields.
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Authors
Jie Zhang, GuangFen Du, YueKe Xu, Lin He, Bin Dai,