Article ID Journal Published Year Pages File Type
5266179 Tetrahedron Letters 2011 4 Pages PDF
Abstract
Radicamine B 5 was synthesized from p-hydroxy benzaldehyde 7 stereoselectively using acid catalysed amido cyclisation with the help of neighbouring group participation (NGP). Without NGP both radicamine B 5 and its epimer 5-epi radicamine B 6 were obtained. The key steps of the synthesis are Sharpless asymmetric dihydroxylations and acid mediated amido cyclisation.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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