Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5266223 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
We describe herein a novel method for the radiolabeling of macromolecules containing primary amine groups. The method utilises radiolabeled acetic acid and exploits commonly used coupling chemistry for conjugation to primary amines in aqueous conditions. The method is a simple, cost-effective, and efficient approach for the small-scale radiolabeling of macromolecules overcoming the many issues of instability when using acetic anhydride as the radiolabeling agent. The use of radiolabeled acetic acid also provides for labeling at a relatively higher specific activity compared to that using acetic anhydride.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ghaith Aljayyoussi, Mark Gumbleton,