| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5266286 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
Using palladium-catalyzed decarboxylation, several cascade reactions of allyl and prenyl nitroalkanoates that lead to nitro-containing chemical building blocks are described. A nitronate Michael addition/Tsuji-Trost allylation cascade was developed, leading to functionally dense chemical building blocks. Likewise, a Tsuji-Trost/decarboxylative protonation sequence was developed for the synthesis of orthogonally functionalized 2° nitroalkanes. The latter method provides rapid access to the indolizidine core.
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Authors
Meghan Schmitt, Alexander J. Grenning, Jon A. Tunge,