Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5266392 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
Peptide formation on the N-terminal of 1-aminoazetidine-2-carboxylic acid is rendered problematic due to a ring opening reaction. However C-terminal development is possible and two diastereomeric mixed hydrazino dipeptides were prepared. Solution-state studies of these compounds suggest the presence of intramolecular hydrogen bonding, consistent with a hydrazino turn, and the crystal structure of one of these compounds shows a horse-shoe conformation, centered around what appears to be a hydrazino turn involving three hydrogen bond acceptors.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Amandine Altmayer-Henzien, Valérie Declerck, Régis Guillot, David J. Aitken,