| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5266425 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A general method for the diastereoselective formation of β-hydroxyketones by the reduction of ketene dimers was developed. Methylphenylketene dimer was reduced with optimal diastereoselectivity (dr up to 6:1) using LiBH4. However, more generally LiAlH4 was found to be the most effective reducing system with respect to diastereoselectivity (dr up to >99:1) and yield (62->99% for 10 examples).
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pei-Hsun Wei, Melanie A. Gary, Divya Nalla, Gero D. Harzmann, Ahmad A. Ibrahim, Kyle R. Dayak, Nessan J. Kerrigan,