Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5266489 | Tetrahedron Letters | 2012 | 8 Pages |
Abstract
Arylidenepyruvic acids (APAs) have been successfully employed in an Ugi-four component condensation reaction which yielded polyfunctional amides. Condensation of various APAs, aldehydes, amines, and isocyanides at room temperature in 96% ethanol as a green solvent proceeded in good yields. The extension of the reaction to diamines, formaldehyde, and isocyanides to form more complex molecules is also reported. These novel products may have potential in various pharmaceutical applications.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bita Soleymanifard, Majid M. Heravi, Morteza Shiri, Mohammad Ali Zolfigol, Mohammad Rafiee, Hendrik G. Kruger, Tricia Naicker, Farzaneh Rasekhmanesh,