Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5266583 | Tetrahedron Letters | 2011 | 14 Pages |
Abstract
Optically active five-membered cyclic nitrones are readily obtained in a one-pot procedure via the organocatalytic Michael addition of aldehydes to nitroolefins and in situ reductive cyclization. Application of the methodology to the synthesis of tricyclic compounds through intramolecular 1,3-dipolar cycloaddition reactions (DFT calculations have also been performed) is also demonstrated. All the reactions were carried out in water as a solvent and excellent ee values (ee >99%) were obtained.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David Sádaba, Ignacio Delso, Tomás Tejero, Pedro Merino,