Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5266729 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
l-Proline efficiently catalyzes the one-pot, three-component reaction of homophthalic anhydride, amines, and aldehydes in CH3CN at room temperature, to afford the corresponding cis-isoquinolonic acids in high yields and with excellent diastereoselectivities. The synthesized compounds are screened for neuroprotective activities.
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Ali Reza Karimi, Hamid Reza Momeni, Rahim Pashazadeh,