Article ID Journal Published Year Pages File Type
5266729 Tetrahedron Letters 2012 4 Pages PDF
Abstract
l-Proline efficiently catalyzes the one-pot, three-component reaction of homophthalic anhydride, amines, and aldehydes in CH3CN at room temperature, to afford the corresponding cis-isoquinolonic acids in high yields and with excellent diastereoselectivities. The synthesized compounds are screened for neuroprotective activities.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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