Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5266830 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
A route to the MDM2-p53 inhibitor isoindolinone pharmacophore from a pre-formed phthalimide is detailed. The route involves treatment of 3-hydroxy-2-(n-propyl)isoindolinone with a substituted benzene in the presence of triflic acid. The resulting 3-aryl-2-(n-propyl)isoindolinones are then oxidized to the corresponding 3-hydroxy-3-aryl-2-(n-propyl) isoindolinones by treatment with 2,2'-bipyridinium chlorochromate. The benzylic oxidation represents a rather rare oxochromium (VI)-mediated reaction in which a selective C-H to C-OH transformation occurs.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Richard K. Dempster, Frederick A. Luzzio,