| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5266836 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
Premnalatifolin A (1), a unique icetexane diterpene dimer was isolated from the stem-bark of Indian medicinal plant, Premna latifolia. Its structure and relative stereochemistry were elucidated on the basis of detailed spectroscopic analysis, including HRESIMS and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectra. The compound has dimeric carbon skeleton composed of two icetexane skeletal diterpenes linked via ether bond. Further, premnalatifolin A (1) was also evaluated for its cytotoxicity against cancer cell lines (HT-29, A-431, MCF-7, Hep-G2, PC-3, A-549, B-16 F10, and ACHN), which displayed potent activity against HT-29 and MCF-7 cell lines with the IC50 values of 12.15 and 1.11 μg/mL, respectively.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
G. Suresh, K. Suresh Babu, M. Suri Appa Rao, V. Rama Subba Rao, P. Ashok Yadav, V. Lakshma Nayak, Sistla Ramakrishna,