| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5266891 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
Bromodimethylsulfonium bromide (BDMS) was found to be a very efficient reagent for Lossen rearrangement of hydroxamic acids to the corresponding isocyanates which were subsequently trapped in situ with various amines to afford unsymmetrical ureas in good to excellent yields (64-89%). The protocol is experimentally simple, mild, and represents valuable alternative to the existing methods for in situ activation of hydroxamic acids promoting Lossen rearrangement.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Deepak K. Yadav, Arvind K. Yadav, Vishnu P. Srivastava, Geeta Watal, Lal Dhar S. Yadav,