| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5266956 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
A calcium catalyzed intramolecular hydroalkoxylation reaction is presented, as a transition metal free, inexpensive, and very mild process for the highly atom economic formation of cyclic ethers from γ,δ-unsaturated alcohols. In contrast to most of the previously reported procedures, room temperature conditions are fully sufficient in most cases for a high yielding cycloisomerization in the presence of a combination of 5 mol-% Ca(NTf2)2 and 5 mol-% Bu4NPF6. Full regioselectivity is observed in all transformations.
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Anastasie Kena Diba, Jeanne-Marie Begouin, Meike Niggemann,