Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5266990 | Tetrahedron Letters | 2011 | 6 Pages |
Abstract
Herein we report an approach to the formation of 5-alkynyl-1,3-dioxin-4-ones using Suzuki-Miyaura cross-coupling reaction of potassium alkynyltrifluoroborate salts with 2,2,6-trimethyl-5-iodo-1,3-dioxin-4-one. The resulting 5-ethynyltrimethylsilyl-1,3-dioxin-4-ones obtained through the Sonogashira reaction were further reacted in a Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition to form functionalized 1,4-disubstituted-1,2,3-triazoles in good yields, using mild conditions and ultrasonic radiation to expedite the reaction.
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Authors
Hélio A. Stefani, Adriano S. Vieira, Mônica F.Z.J. Amaral, Leora Cooper,