| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5267037 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
The Diels-Alder reaction of (E)-2-styrylchromones with a pyrimidine ortho-quinodimethane is reported for the first time. These cycloaddition reactions afford mixtures of two regioisomeric tetrahydroquinazoline-substituted chromones in moderate to excellent global yields. Irrespective of the substituents on the 2-styrylchromones, the 2-(7-aryl-4-methoxy-2-methyl-5,6,7,8-tetrahydroquinazolin-6-yl)chromone derivatives are always the major isomers.
Graphical abstractThe Diels-Alder reaction of (E)-2-styryl chromones with a pyrimidine ortho-quinodimethane yields a mixture of two isomeric 5,6,7,8-tetrahydroquinazoline-substituted chromones.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Diana T. Patoilo, Artur M.S. Silva, Diana C.G.A. Pinto, Clementina M.M. Santos, Augusto C. Tomé, José A.S. Cavaleiro,