| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5267069 | Tetrahedron Letters | 2016 | 14 Pages |
Abstract
Two new parthenolide analogues were obtained by total synthesis and assayed for their in vitro anticancer activities to study their structure-activity relationship. Based on the structure and anticancer activity results, two new SAR can be drawn: (1) replacement of the lactone moiety with lactam moiety greatly decreased the anticancer activity; (2) the C-14 methyl group of parthenolide might be important for its high anticancer activity.213
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Authors
Jing Long, Ya-Hui Ding, Pan-Pan Wang, Quan Zhang, Yue Chen,