| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5267100 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
We report the synthesis of the near infrared (NIR) fluorescent porphyrazine (Pz) 285, with pendant hydroxyl groups, as a non-toxic platform for delivery of conjugated chemotherapeutic agents to tumor cells. Conjugation of Pz 285 to Doxorubicin via an acid labile linker and initial biological studies are reported.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Evan R. Trivedi, Carl M. Blumenfeld, Todd Wielgos, Sharon Pokropinski, Prasad Dande, Ton T. Hai, Anthony G.M. Barrett, Brian M. Hoffman,