Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5267103 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
An efficient and regioselective procedure for the synthesis of a series of alkyl(aryl/heteroaryl) substituted 3-trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs, from the cyclocondensation reactions of 4-alkoxy-1,1,1-trihaloalk-3-en-2-ones [CX3C(O)CR2=CR1(OMe/OEt), where R1 = H, Me, Ph, 2-Furyl; R2 = H; R1-R2 = -C4H8- and X = F, Cl] and 1-phenylsemicarbazide in an acidified alcoholic medium (R3OH/H2SO4), where R3 = Me, Et, Pri was successfully applied and is described here in detail.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Helio G. Bonacorso, Michele S. Correa, Liliane M.F. Porte, Everton P. Pittaluga, Nilo Zanatta, Marcos A.P. Martins,