Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5267213 | Tetrahedron Letters | 2012 | 5 Pages |
Abstract
Two new phloroglucinols, named eucalyptals D (1) and E (2), along with a related known compound (euglobal-In-3, 3) were isolated from the fruits of Eucalyptus globulus. Their structures were established on the basis of extensive spectroscopic studies, revealing that they share a common 3,5-diformyl-isopentyl phloroglucinol unit, but each is instead coupled to a different sesquiterpenoid skeleton (aromadendrene in 1, cadinene in 2, and a spirosesquiterpene in 3). Compound 1 possessed an unusual seven-membered D ring with an ether bridge between C-2 of the aromadendrene moiety and C-2â² of the aromatic unit. The absolute configuration of the isolates was defined by the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1-3 exhibited significant in vitro cytotoxicities against a few human cancer cell lines (Huh-7, Jurkat, BGC-823, and KE-97) using the CellTiter-GloTM luminescent cell viability assay method.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ji Wang, Wen-Zhu Zhai, Yike Zou, Jing-Jing Zhu, Juan Xiong, Yun Zhao, Guo-Xun Yang, Hui Fan, Mark T. Hamann, Gang Xia, Jin-Feng Hu,