Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5267269 | Tetrahedron Letters | 2012 | 5 Pages |
Abstract
An oxidative amide formation using N-hydroxysuccinimide and hypervalent iodine reagents was developed. The method enables a wide range of aldehydes and amines to be coupled under mild reaction conditions providing amide in good to excellent yield. The radical species in the reaction mixture was observed for the first time using ESR measurement, and along with other mechanistic investigations, a plausible mechanism of the reaction was proposed.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Haoyi Yao, Yun Tang, Kana Yamamoto,