Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5267272 | Tetrahedron Letters | 2012 | 10 Pages |
Abstract
The regioselective ring opening of the commercially available N-(2,3-epoxypropyl)phthalimide with different nucleophiles, to obtain the corresponding phthalimidopropan-2-ols (including a challenging fluorohydrin) followed by the Dess-Martin periodinane oxidation, constitutes a general and widely applicable protocol for the preparation of differently functionalized α-phthalimido-αâ²-substituted propan-2-ones. The incorporation of the substituent in the αⲠposition takes place in an early stage of the process, thus furnishing a divergent and valuable approach.
Related Topics
Physical Sciences and Engineering
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Authors
Vittorio Pace, Wolfgang Holzer,