| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5267330 | Tetrahedron Letters | 2015 | 4 Pages |
Abstract
A robust synthetic method has been developed as an improvement to the venerable Skraup-Doebner-Von Miller reaction providing access to various quinoline products. The straightforward procedure utilizes acrolein diethyl acetal as a three-carbon annulation partner with aniline substrates in a monophasic, organic solvent-free reaction medium. Differentially substituted aniline precursors were found to be compatible with the reaction conditions and the corresponding quinoline products are isolated in moderate to good yields.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ginelle A. Ramann, Bryan J. Cowen,