| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5267405 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
Over the course of developing a multigram scale preparation of epoxy quinol 1 via asymmetric transfer hydrogenation (ATH) using the Noyori Ru(arene)(S,S-TsDPEN) catalysts, we observed several unexpected phenomena, including (i) chemoselective alkene versus ketone reduction of an enedione, (ii) a significant arene ligand effect (p-cymene vs mesitylene) on the reaction pathway, and (iii) solvent-based reversal of the sense of enantioinduction.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David R. Clay, Matthias C. McIntosh,