| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5267556 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
ortho-Mercaptobenzoic acid and ortho-mercaptophenols were discovered as efficient thiol catalysts of both the intramolecular Morita-Baylis-Hillman (MBH) and Rauhut-Currier (RC) reaction. High reaction rates were achieved under mildly basic, aqueous conditions. The unprecedented catalytic activity of these protic nucleophiles could originate from a Brønsted acid induced destabilization of intermediate thioethers and thus represent a unique mechanism of multifunctional Lewis base catalysis.
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Authors
Philipp S. Selig, Scott J. Miller,