| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5267583 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
Synthetic approach towards precursors of WS75624 A and WS75624 B, two potent endothelin converting enzyme (ECE) inhibitors and potential antihypertensive agents, is reported featuring a key cross-metathesis between a vinyl-functionalized thiazole and a terminal olefin. As the two natural products only differ by the nature of their hydroxyalkyl side-chain, our convergent strategy enable the synthesis of key intermediates of both molecules in a limited amount of steps.
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Authors
Jyotirmayee Dash, Bruno Melillo, Stellios Arseniyadis, Janine Cossy,