| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5267651 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
Phosphatidylcholine analogues were synthesised as affinity ligands for the capture of membrane proteins. Several protecting group strategies were investigated to synthesize the amino-functionalized phosphatidylcholine: 11-aminoundecyl 2-(trimethylammonio)ethyl phosphate (4). The acid-mediated deprotection of the Boc group generated a mixture of the target products which could only be purified by HPLC. However, an alternative strategy, using the hydrazine-labile phthalimide group route, followed by a gel filtration step proved straightforward to afford the desired amino-functionalized phosphatidylcholine product in high yield and purity.
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Organic Chemistry
Authors
Fanzhi Kong, Goreti Ribeiro Morais, Robert A. Falconer, Chris W. Sutton,