| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5267734 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
A three-component diastereoselective vinylogous Mannich-type reaction (VMR) with the silyl ketene acetal (1) was developed. Adducts from the reactions provided valuable intermediates for construction of a variety of chiral 6-alkylated piperidinone and 2-piperidine compounds. The strategy was applied in a concise synthesis (S)-anabasine.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yang Yang, Dean P. Phillips, Shifeng Pan,