| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5267746 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
The preparation of a heterogeneous bifunctional catalytic system, combining the catalytic properties of an organometallic catalyst (racemization) with those of an enzyme (enantioselective acylation) is described. A novel ruthenium phosphonate inhibitor was synthesized and covalently anchored to a lipase immobilized on a solid support (CALB, Novozym® 435). The immobilized bifunctional catalytic system showed activity in both racemization of (S)-1-phenylethanol and selective acylation of 1-phenylethanol.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Birgit Wieczorek, Annika Träff, Patrik Krumlinde, Harm P. Dijkstra, Maarten R. Egmond, Gerard van Koten, Jan-Erling Bäckvall, Robertus J.M. Klein Gebbink,