| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5267754 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
We report a convenient single-flask methodology for the preparation of polyazatriaryl products with relevance to luminescence, catalysis, and pharmacology. The diborylation of 1,3-dibromobenzenes and double Suzuki-Miyaura coupling produces 1,3-diheteroarylbenzenes. Similarly, borylation of heteroaryl halides and double coupling to 2,6-dichloropyridine produces 2,6-diheteroarylpyridines. This methodology appears general in producing challenging polyheteroaryl targets as long as the boronic esters have no ortho heteroatoms and coupling avoids adjacent oxygens.
Related Topics
Physical Sciences and Engineering
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Authors
Bertoldo Avitia, Eric MacIntosh, Samuel Muhia, Eric Kelson,