Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5267768 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
An efficient preparation of highly enantiomerically enriched aryl β-hydroxy α-amino esters via dynamic kinetic resolution (DKR), asymmetric transfer hydrogenation of α-amino β-keto esters is described. The anti β-hydroxyl α-amino esters were obtained both in high yields and high diasteroselectivity. The observed high anti selectivity is inconsistent with the previous results in literature. The absolute stereochemistry of the aryl β-hydroxy α-amino esters was unambiguously confirmed via chemical derivatization as well as Vibrational Circular Dichroism (VCD) techniques.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhuqing Liu, C.Scott Shultz, Candice A. Sherwood, Shane Krska, Peter G. Dormer, Richard Desmond, Claire Lee, Edward C. Sherer, Joseph Shpungin, James Cuff, Feng Xu,