Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5267825 | Tetrahedron Letters | 2012 | 5 Pages |
Abstract
Sodium azide has been found to catalyse Knoevenagel condensation between aromatic aldehyde and cyano compound with active methylene hydrogens and this has led to a successful route for the one pot synthesis of 4,5-disubstituted 1,2,3-(NH)-triazoles from aldehydes through Knoevenagel-[3+2]cycloaddition-elimination sequence. In the formation of 5-aryl-2H-1,2,3-triazole-4-carbonitrile derivatives, the reaction has been found to occur efficiently in water.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thanasekaran Ponpandian, Shanmugam Muthusubramanian,