Multicomponent [3+2] cycloaddition strategy: stereoselective synthesis of novel polycyclic cage-like systems and dispiro compounds

The syntheses of novel structurally intriguing hexacyclic cage-like compounds have been achieved from the three-component tandem [3+2] cycloaddition-intramolecular annulation reactions of ninhydrin, α-amino acids and (E)-3-arylidene-1-methylpiperidin-4-ones.142