Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5267899 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
A straightforward method of creating a bifunctional support possessing pre-defined ratios of amine and chloromethyl groups based upon a controlled conversion of standard Merrifield resin is presented. It avoids the extensive optimisation of reactant concentrations and reaction conditions required by existing methods. Furthermore, it avoids increases in the spacer/linker length that lead to detrimental reductions in the rigidity of the grafted layer. The method will allow for efficient, predictable and reproducible co-immobilisation of molecular species.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jenna L. Bowen, Marc A. Kelly, Mark Gumbleton, Philip R. Davies, Chris J. Allender,