Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5267947 | Tetrahedron Letters | 2015 | 5 Pages |
Abstract
A general methodology for the three step synthesis of macrocyclic peptidomimetic fluorophores with a range of ring size from 15 to 18 is described. The alternate Mannich type reaction between the halogen functionalized long chain alkyl nitriles with aldehydes and ketones in which one of them decorated with an alkyne functionality leads to the key precursor for the intramolecular copper catalyzed [3+2] azide-alkyne cycloaddition to make the macrocycles obeying Lipinski's rule of five.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
P. Jithin Raj, D. Bahulayan,