| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268013 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
The synthesis of dihydroxy-isoindolinone-carboxylates from a dioxinone keto-ester and N-protected sarcosine without the use of phenolic protection is described. Base-induced aromatization of the dioxinone diketo-ester followed by lactamization furnished the desired dihydroxy-isoindolinone moiety, which could be used as an EF-ring precursor toward the synthesis of lactonamycin.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sylvain A. Jacques, Bhavesh H. Patel, Anthony G.M. Barrett,