A facile one-pot synthesis of Nα-Z/Boc-protected S-linked 1,3,4-oxadiazole tethered peptidomimetics

Synthesis of Nα-protected S-linked 1,3,4-oxadiazole tethered peptidomimetics is described by the reaction of Nα-Z/Boc-protected 1,3,4-oxadiazole-2-thiol with α-bromo ester. Further, the protocol has been extended for the synthesis of glycosylated and N,N′-orthogonally protected S-linked 1,3,4-oxadiazole tethered mimetics. In addition, the chain extension of Nα-Z/Boc-protected S-linked 1,3,4-oxadiazolyl tethered dipeptidomimetic on both N- as well as C-terminal was also demonstrated.