Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5268142 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
The ring-enlargement reactions of monochloro-β-lactam-fused 2-aryl-1,3-benzothiazines revealed that the reactions of ortho-nitro aryl-substituted derivatives with sodium methoxide in methanol provided two products, depending on the amount of the base. With 2 equiv of reagent, the expected 1,4-benzothiazepines were obtained. Somewhat surprisingly, treatment with a large excess of sodium methoxide led to the formation of indolo-1,4-benzothiazepines via a novel rearrangement. The structures of the new ring systems were determined by means of X-ray crystallography and NMR spectroscopy.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lajos Fodor, Péter Csomós, Tamás Holczbauer, Alajos Kálmán, Antal Csámpai, Pál Sohár,