| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268154 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
The direct transformation of various secondary amides into N-arylimidates via mild electrophilic amide activation with trifluoromethanesulfonic anhydride (Tf2O) in the presence of 2-chloropyridine (2-ClPyr) is described. Low-temperature amide activation followed by C-O bond formation with 2-naphthol provides the desired N-arylimidates in short overall reaction times. In contrast, reaction with oxindole proceeds via formation of a C-C bond to give 1-(1H-indol-2-yl)naphthalene-2-ol.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mehdi Ghandi, Saleh Salahi, Mohammad Hasani,