| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268197 | Tetrahedron Letters | 2015 | 5 Pages |
Abstract
A series of 2-(acetamide-2-yl)-imidazolines (II) with 5 points of diversity were prepared by an Ugi-4CR-Staudinger-aza-Wittig-sequence starting from simple azidoalkylamines. The intramolecular aza-Wittig cyclization between the iminophosphane and the tertiary amide of the Ugi product (I) was effected by short microwave irradiation. Competitive cyclization to the secondary amide was not relevant, however, in some cases subsequent formation of the bicyclic ortho-amidines (III) was observed.
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Organic Chemistry
Authors
Sebastian J. Welsch, Michael Umkehrer, Cedric Kalinski, Günther Ross, Christoph Burdack, Jürgen Kolb, Martina Wild, Anja Ehrlich, Ludger A. Wessjohann,