Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5268238 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
We demonstrate the synthesis of various purine derivatives through the coupling of N4-methyl-2-morpholin-4-yl-pyrimidine-4,5-diamine with various aldehydes by using polyphosphoric acid (PPA) as an efficient catalyst in DMF at reflux temperature. The PPA catalyst gave better yields (70-85%) in short reaction times (45-60Â min). This commercially available cheap catalyst is more active than many reported expensive catalysts. Many aldehydes underwent the above conversion to form a series of 9-methyl-2-morpholin-4-yl-8-phenyl-9H-purines.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
P. Sadanandam, V. Jyothi, M. Adharvana Chari, Parthasarathi Das, K. Mukkanti,