Article ID Journal Published Year Pages File Type
5268238 Tetrahedron Letters 2011 4 Pages PDF
Abstract

We demonstrate the synthesis of various purine derivatives through the coupling of N4-methyl-2-morpholin-4-yl-pyrimidine-4,5-diamine with various aldehydes by using polyphosphoric acid (PPA) as an efficient catalyst in DMF at reflux temperature. The PPA catalyst gave better yields (70-85%) in short reaction times (45-60 min). This commercially available cheap catalyst is more active than many reported expensive catalysts. Many aldehydes underwent the above conversion to form a series of 9-methyl-2-morpholin-4-yl-8-phenyl-9H-purines.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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