Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5268239 | Tetrahedron Letters | 2011 | 5 Pages |
Polyfluoroarenes can be cross-coupled with simple aromatics (benzene, toluene, and anisole), in good isolated yields, by using Pd(OAc)2 dissolved in imidazolium ILs [(bmim)PF6 and (bmim)BF4] as solvent, without the need for an oxidant and an additive. The reaction is catalyzed by HOAc and it is subject to a primary isotope effect (KH/KDÂ =Â 4.87). Competitive cross-coupling reactions of 1,2,4,5-tetrafluorobenzene with benzene/toluene, benzene/anisole, and anisole/toluene gave KB/KTÂ =Â 5.1, KB/KAÂ =Â 5.7, and KA/KTÂ =Â 5.0, respectively, indicative of a remote substituent effect on Pd insertion into the phenyl C-H bond. Mild reaction conditions, simple product isolation and recycling/reuse of the IL are additional advantages of this method.
Graphical abstractDownload full-size image