| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268338 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
A route to selective functionalization of polyhydroxypyrrolidines is described. The method is based on orthogonal protection/deprotection along the process of synthesis of the referred pyrrolidines, which consist in hydroxylation of the double bond of 2-azabicyclo[2.2.1]hept-5-enes followed by its oxidative cleavage and in situ reduction of the intermediate dialdehyde. The synthesis of a novel N-hydroxypyrrolidine is also described.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Carlos A.D. Sousa, Fabio Rizzo-Aguiar, M. LuÃsa C. Vale, Xerardo GarcÃa-Mera, Olga Caamaño, José E. RodrÃguez-Borges,