| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268369 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
Treatment of 2-(2-oxo-2-arylethylthio)-N-(4H-1,2,4-triazol-3-yl)acetamides with paraformaldehyde in the presence of a base has led to a tandem chemoselective hydroxymethylation followed by cyclization yielding a set of novel 6-aroyl-4-(4H-triazol-3-yl)thiomorpholin-3-ones. The thiomorpholine ring has been found to have a boat like conformation in these compounds as evidenced by NOESY NMR spectrum.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thulasiraman Krishnaraj, Shanmugam Muthusubramanian,