Article ID Journal Published Year Pages File Type
5268393 Tetrahedron Letters 2015 5 Pages PDF
Abstract

The Sonogashira coupling reaction of 3-chloro-1H-isochromen-1-one and terminal alkynes, in the presence of catalytic system-Pd(OAc)2/Ruphos, Et3N base, and tetrahydrofuran solvent under aqueous conditions, provided novel 3-(alkynyl)-1H-isochromen-1-ones in excellent yields. The methodology has also been extended toward natural isochromen-1-ones-corfin analogues.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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