Stereoselective synthesis of higher homologues of pantolactone from (R)-glyceraldehyde acetonide

A stereoselective synthetic route has been developed toward the synthesis of novel γ-substituted pantolactone homologues using Sharpless asymmetric dihydroxylation of the enantiomeric alkene–ester intermediates, derived from (R)-glyceraldehyde acetonide, as the key step.

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