| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268427 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
An efficient synthesis of non-activated 2-(chloromethyl)aziridines and 2-chloromethyl-2-methylaziridines as new representatives of the class of 2-(halomethyl)aziridines was developed. Furthermore, the reactivity of these azaheterocycles was assessed and compared to that of their brominated counterparts, pointing to a similar profile for 2-(chloromethyl)aziridines and 2-(bromomethyl)aziridines on the one hand, and a different behaviour of 2-chloromethyl-2-methylaziridines versus 2-bromomethyl-2-methylaziridines concerning their aptitude towards ring expansion to azetidines on the other hand.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sonja StankoviÄ, Matthias D'hooghe, Jo Dewulf, Piet Bogaert, Robrecht Jolie, Norbert De Kimpe,