Total synthesis of fluvirucinine A1

An efficient and highly stereocontrolled convergent synthesis of fluvirucinine A1 is reported herein. In fluvirucinine A1 both C5-C13 and C1-C4 fragments were accessed from a common intermediate 6 derived from (S)-Roche ester in 15 and 7 steps, respectively. The key steps involve Evans asymmetric alkylation, Sharpless asymmetric epoxidation, amidation and a ring-closing metathesis reaction (RCM) for macrocyclization.

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