Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5268450 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
The electroreductive intramolecular coupling of aliphatic cyclic imides with ketones in isopropanol gave five- and six-membered cyclized products. Similarly, the electroreductive intramolecular coupling of aliphatic cyclic imides with O-methyloximes afforded five-, six-, and seven-membered cyclized products. These reactions provide a useful method to synthesize azabicyclo[n.m.0] compounds. The bicyclic products were stereoselectively transformed to the corresponding deoxylated compounds by reduction with NaB(CN)H3 or Et3SiH/BF3·Et2O.
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Authors
Naoki Kise, Kazuaki Fukazawa, Toshihiko Sakurai,